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purebmc® supraphysiologic
autologous power of progenitor stem cells
PureBMC® SupraPhysiologic offers the ideal solution for bone marrow cell concentration. This advanced technology provides a potent and viable cell concentrate from the bone marrow environment, enhancing the function of platelets, total nucleated cells, mesenchymal stem cells, and hematopoietic stem cells. This results in improved cell proliferation, chemotaxis, migration, and expression, leading to significantly better clinical outcomes.
What sets PureBMC® SupraPhysiologic apart is that it does NOT contain the high levels of plasma free hemoglobin commonly found in other bone marrow cell concentrates, while offering elevated concentrations of viable platelet growth factors—an exclusive feature of this biologic. The secret lies in the sophisticated preparation technology, combined with the ASPIRE™ Bone Marrow Harvesting System, which enables a minimally invasive, pure collection of bone marrow aspirate.
For further details or to inquire about advanced clinical training, call us at +353 (0) 1 298 8000.
Leading in Biologic Power
PureBMC® SupraPhysiologic is an autologous bone marrow concentrate (BMC) that represents the forefront of modern progenitor stem cell medicine, widely accepted in clinical practice for treating a range of pathologies. It promotes tissue healing and regeneration by providing a concentrated mix of differentiating stem cells, including hematopoietic, mesenchymal, and total nucleated cells, along with platelets, cell mediators, and cytokines.
The use of PureBMC® offers a point-of-care, minimally invasive biologic solution that enhances biologic therapies by adding the power of self-renewal and differentiation. This approach is particularly effective for musculoskeletal disorders, spinal issues, chronic wound care, critical limb ischemia, and a variety of other injuries and wounds. As a vital component of the rapidly expanding field of regenerative medicine, PureBMC® SupraPhysiologic stands as the leading-edge solution in bone marrow concentration, offering unmatched biologic power, safety, efficiency, and superior clinical outcomes.
Reduced Clotting
Coagulation studies indicate no significant difference in clotting time between plasma and PureBMC SupraPhysiologic (SP). The quiescent aspiration technique used in the ASPIRE Harvesting System minimizes clot activation, helping to preserve cell function throughout the collection and processing stages. This demonstrates that PureBMC SP is processed in a way that maintains the integrity and functionality of progenitor stem cells, platelets, and platelet growth factors.
Minimized Free Hemoglobin
Free hemoglobin in the extracellular space is associated with several pathologies and negative clinical outcomes, including oxidative damage, nitric oxide depletion, oxidative stress, hypertension, vaso-occlusion, immune dysfunction, renal failure, and more. PureBMC® SP offers a highly pure bone marrow concentrate with significantly lower levels of free hemoglobin compared to other leading systems. Its specialized collection method effectively reduces hemolytic free hemoglobin, ensuring a cleaner sample.
Reduced Activation
PureBMC® ensures a progenitor cell viability of 97% or higher, largely thanks to its gentle processing method and the quiescent aspiration achieved with the ASPIRE™ bone marrow needle. This needle features an ergonomic, lightweight handle for consistent pressure application during use, a precision-engineered triple crown bevel tip for minimally invasive coring of cortical bone, and a uniquely designed fenestrated blunt tip aspirating cannula that enables optimal sample collection while preserving cell integrity.
biology of purebmc® biologic
Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) have the remarkable ability to self-renew and differentiate into all types of blood cells, demonstrating their multipotent nature. These cells can regenerate monocytes, macrophages, erythrocytes, megakaryocytes, platelets, neutrophils, basophils, eosinophils, dendritic cells, and lymphoid lineage cells. Such cell types play an essential role in supporting the regenerative processes required for effective tissue repair. HSCs are primarily found in the pelvic, femoral, and sternal bone marrow, offering both long-term and short-term regenerative potential.
Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are multipotent stromal cells capable of differentiating into various cell types, such as cartilage, bone, and adipose tissue. While MSCs are present in relatively small amounts in bone marrow aspirates, the viable ones possess remarkable proliferative abilities, making them a potent biological resource for regenerative therapies.
Total Nucleated Cells
The total nucleated cell (TNC) count refers to the number of cells with nuclei present. To accurately reflect the TNC count, a correction is applied to exclude nucleated red blood cells (nRBCs). The total nucleated cell count serves as a general indicator of the quality of the bone marrow concentrate product.
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